以(S)-苯乙胺和丙烯酸甲酯为原料,方便地合成了一对非对映的氮杂醇手性配体,研究了它们在锌催化的不对称的Henry反应中不对称催化效果,β-硝醇的加成产物达到中等的催化效果(高达64%的ee值)。同时探讨了可能的催化机理。 A series of diastereomeric azain alcohol chiral ligands were synthesized with (S) -phenethylamine and methyl acrylate as starting materials and their asymmetric catalysis in zinc catalyzed asymmetric Henry reaction was studied , the addition of β-nilanol achieved a moderate catalytic effect (up to 64% ee). At the same time, the possible catalytic mechanism was explored.