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目的 进行冠心病冠状动脉粥样硬化(AS)发生的危险因素多因素Logistic分析,为AS的预防提供循证依据.方法 回顾性纳入2014年12月至2017年12月淮南市朝阳医院心内科收治的100例AS以及100例非AS的住院患者,分别设为观察组与对照组.调查两组患者性别、年龄、体质指数(BMI)、职业等一般资料、吸烟史以及糖尿病等合并症以及血脂水平,采用单因素与多因素Logistic回归分析探讨AS的独立危险因素.结果 两组年龄、性别、BMI等一般资料差异具有统计学意义(P ＜0.05);职业、学历、婚姻、子女情况差异无统计学意义(P＞ 0.05);两组吸烟史、饮酒史、合并糖尿病、高血压差异具有统计学意义(P ＜0.05);两组总胆固醇(TC)、载脂蛋白A1(Apo A1)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(Apo B)、高密度脂蛋白胆固醇(HDL-C)差异具有统计学意义(P＜0.05);多因素Logistic回归分析结果显示男性(OR=3.321,95％CI:2.007～11.622)、吸烟史(OR=2.456,95％CI:1.332～7.543)、糖尿病(OR=2.765,95％CI:2.032～9.665)、LDL-C＞ 3.1 mmol/L(OR=3.154,95％CI:1.231～12.434)、高血压(OR=2.432,95％CI:1.322～10.323)是AS的独立危险因素.结论 男性、吸烟史、糖尿病、LDL-C＞ 3.1 mmol/L、高血压均是发生AS的独立危险因素.“,”Objective To make multivariate Logistic analysis of the risk factors of the coronary atherosclerosis (AS) formation in patients with coronary heart disease, so as to provide theoretical basis for the prevention of AS. Methods 100 AS patients admitted to our hospital from December 2014 to December 2017 and 100 non-AS outpatients were enrolled and included into observation group and control group respectively.The general data such as sex, age, occupation, smoking history, complications such as diabetes mellitus and blood lipid levels were investigated in both groups. Then univariate and multivariate logistic regression analysis were used to explore the independent risk factors of AS. Results The general data such as age, gender and BMI between the two groups had significant differences (P ＜ 0. 05), while no difference was found in the occupation, education, marital status, and the number of children (P＞ 0. 05); The differences of smoking history, drinking history, diabetes and hypertension in the two groups were statistically significant (P ＜ 0. 05). And the differences of TC, ApoA1, TG, LDL-C, ApoB and HDL-C between the two groups were also statistically significant (P ＜ 0. 05). Multivariate logistic regression analysis showed that male (OR =3. 321, 95％ CI: 2. 007 ～ 11. 622), smoking history (OR = 2. 456, 95％ CI: 1. 332 ～ 7. 543), diabetes mellitus (OR = 2. 765, 95％ CI: 2. 032～ 9. 665), LDL-C＞ 3. 1 mmol/L (OR = 3. 154, 95％ CI: 1. 231 ～ 12. 434), hypertension (OR = 2. 432, 95％ CI: 1. 322 ～ 10. 323) were independent risk factors for AS. Conclusion Male, smoking history, diabetes mellitus, LDL-C＞ 3. 1 mmol/L, hypertension were all independent risk factors of AS.