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劳累性心绞痛38例采用噻吗洛尔2.5-5mg, tid,共4wk;另12例采用普萘洛尔10-20mg, tid,共4wk。结果:前者显效率为79％,显著高于后者42％(P<0.05)。高血压病(Ⅰ,Ⅱ期)37例采用噻吗洛尔治疗,方法同上;另13例采用普萘洛尔20-40mg, tid,疗程亦4wk。结果:2组均有显著降压疗效(P<0.01),噻吗洛尔治疗后1h即获显效,普萘洛尔须24h才获显效。噻吗洛尔7％(5/75)、普萘洛尔4％(1/25)治疗后发生窦性心动过缓,前者被迫停药,后者未停药。
38 cases of exertional angina pectoris with 2.5-5mg, tid, a total of 4wk; the other 12 cases with propranolol 10-20mg, tid, a total of 4wk. Results: The former markedly effective rate was 79%, significantly higher than the latter 42% (P <0.05). Hypertension (Ⅰ, Ⅱ) 37 cases of timolol treatment, the same way as above; the other 13 cases with propranolol 20-40mg, tid, treatment also 4wk. Results: Both groups were significantly antihypertensive effect (P <0.01), 1 h after timolol treatment was markedly effective, propranolol 24 h was markedly effective. Timolol 7% (5/75), propranolol 4% (1/25) after treatment of sinus bradycardia, the former was forced to stop the latter without stopping the drug.