论文部分内容阅读
目的制备用于中枢镇痛的氢溴酸高乌甲素鼻用凝胶。方法以AvicelRC/Cl为基质,制备氢溴酸高乌甲素鼻用混悬凝胶,并对混悬凝胶的流变学性质、体外释药特性和药效进行初步评价。结果流变学性质考察结果表明,鼻用混悬凝胶具有良好触变性,随着剪切力的降低,混悬凝胶黏度迅速增加;体外释放试验结果表明,混悬凝胶静置形成的半固体凝胶具有一定缓释效果;药效评价结果表明,小鼠经鼻给予氢溴酸高乌甲素混悬凝胶相对于静脉给药,能缩短起效时间,增加药物效应强度,与经鼻给予氢溴酸高乌甲素溶液相比,能延长药物作用时间。结论本研究制备的氢溴酸高乌甲素鼻用混悬凝胶能够快速起效,并维持一定时间,适用于战创伤的镇痛救治。
Objective To prepare lappaconitine nasal hydrobromide gel for central analgesia. Methods Based on Avicel RC / Cl, the lactiding hydrobromide nasal suspension gel was prepared and the rheological properties, in vitro release characteristics and drug efficacy of the suspension gel were preliminarily evaluated. The results of the rheological properties of the investigation showed that the nasal suspension gel has good thixotropy, with the shear force decreases, the viscosity of the suspension gel increases rapidly; release test results show that the suspension gel standing Semi-solid gel with a sustained release effect; efficacy evaluation results show that nasal administration of lappaconite hydrobromide gel relative to intravenous administration, can shorten the onset time and increase the drug effect strength, and Nasal administration of lappaconitine hydrobromide solution compared to the drug can extend the role of time. CONCLUSION The lappaconitine hydrobromide nasal suspension gel prepared in this study can rapidly take effect and maintain for a certain period of time and is suitable for the analgesic treatment of war wounds.