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对非感染大鼠和感染大鼠,在腹腔注射两性霉素B或两性霉素B加利福平后进行了血清浓度测定。两性霉素B的血清浓度在人接受该药治疗时,是易于达到的。动物接受二种药物时的两性霉素B血清浓度始终高于单独接受两性霉素B时的血清浓度。 过去未曾证明两性霉素B和利福平联合应用对播散性念珠菌病有协同作用。本文在体内实验中,采用完善建立的大鼠播散性和致命性念珠菌病模型,利福平对两性霉素B的增强作用被明显地证实。这种增强作用是由于协同作用,还是由于二者联合时两性霉素B的血浓度增高,尚有待阐明。
Serum concentrations were measured in non-infected and infected rats after intraperitoneal injection of amphotericin B or amphotericin B and rifampicin. The serum concentration of amphotericin B is readily achievable when administered to humans. Amphotericin B serum concentrations were consistently higher in animals receiving both drugs than in amphotericin B alone. In the past, no combination of amphotericin B and rifampicin has been shown to have a synergistic effect on disseminated candidiasis. In vivo experiments, the establishment of a well-established model of disseminated and fatal candidiasis in rats, rifampin enhance the role of amphotericin B was clearly confirmed. Whether this potentiation is due to synergism or the increased blood concentration of amphotericin B when the two are combined remains to be elucidated.