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在麻醉开胸狗观察了急性心肌缺血对血液流变学和心脏收缩功能改变的影响。在阻断狗前降支冠脉1h内,血液流变学各参数发生异常变化,表现为高、低切变率下全血粘度(ηbh、ηb1)、血浆粘度、血细胞压积和纤维蛋白原升高,红细胞电泳时间缩短。同步描记心电、心音和颈动脉搏动图而记录的心脏收缩时间间期,表现为射血前期(PEP)延长、左室射血时间(LVET)缩短和PEP/LVET比值增大。此外,动脉舒张压(DAP)升高,心输出量(CO)减少。上述各参数均与对照值有明显差异,P<0.05。缺血40min时,对ηb1和PEP/LVET或DAP进行相关分析,呈明显正相关,P<0.05;ηb1和CO呈明显负相关,P<0.01。结果提示,心肌缺血后发生的血液流变学异常变化,具有增加射血阻力和减少心输出量的作用。
The effects of acute myocardial ischemia on hemorheology and cardiac contractile function were observed in anesthetized open-chest dogs. Within 1 h of blocking the anterior descending coronary artery, the parameters of hemorheology changed abnormally, which were the whole blood viscosity (ηbh, ηb1), plasma viscosity, hematocrit and fibrinogen at high and low shear rate Rise, shorten the time of erythrocyte electrophoresis. Simultaneous tracing of ECG, heart sounds and carotid artery pulsation maps recorded systolic time intervals with prolonged pre ejection (PEP), shortened LVET, and increased PEP / LVET ratio. In addition, arterial diastolic blood pressure (DAP) increased, cardiac output (CO) decreased. The above parameters were significantly different from the control value, P <0.05. Correlation analysis between ηb1 and PEP / LVET or DAP showed a significant positive correlation (P <0.05) at 40 min ischemia, and negative correlation between ηb1 and CO, P <0.01. The results suggest that abnormal changes in hemorheology occurring after myocardial ischemia have the effect of increasing blood pressure resistance and reducing cardiac output.