在离体兔股动脉,利多卡因和普鲁卡因均可使去甲肾上腺素(NA)浓度-效应曲线右移,两药在浓度为1mmol/L时,NA的等效浓度分别是对照的5.6和2.9倍;在3mmol/L时,为70.5和14.6倍。从NA浓度-效应曲线观察到利多卡因对抗NA所致的血管收缩作用更明显。对于预先用NA引起的血管收缩,利多卡因及普鲁卡因均可使之舒张,其IC_(50)分别为1.3与2.1 mmol/L。两药合用,用等效线提示为相加作用。 The noradrenaline (NA) concentration-response curves were shifted to the right in isolated rabbit femoral arteries, lidocaine and procaine, respectively. The equivalent concentrations of NA at the two concentrations of 1 mmol / L were control Of 5.6 and 2.9 times; at 3mmol / L, 70.5 and 14.6 times. It was observed from the NA concentration-response curves that vasoconstriction by lidocaine against NA was more pronounced. For pre-NA-induced vasoconstriction, both lidocaine and procaine exerted an antihypertensive effect with IC50 values ​​of 1.3 and 2.1 mmol / L, respectively. Combination of two drugs, with the equivalent line prompts for the additive effect.