丝裂蒽醌(Mitoxantrone,商品名Novantrone,NVT)是模拟阿霉素(Adria-mycine,ADM)等蒽环类(Anthracyclines)结构而合成的蒽二酮类化合物,企求具有ADM相似的抗癌疗效而心脏毒性减低。经动物实验证明对多种肿瘤有效。White等报告在体外试验中本药可杀伤增殖中及非增殖中的细胞。药物作用后癌细胞倾向积累于G_2期。推测其作用机理可能嵌入DNA中,经Foye实验,确证它能与DNA及RNA结合。但Alberts等又证明它与L1210细胞的 Mitoxantrone (trade name Novantrone, NVT) is an anthracenedione compound that mimics the structure of anthracyclines such as Adriamycin (ADM), and seeks to have similar anti-cancer efficacy of ADM. The cardiotoxicity is reduced. Animal experiments have proven effective against a variety of tumors. White et al. reported that the drug kills both proliferating and nonproliferating cells in vitro. Cancer cells tend to accumulate in G2 phase after drug treatment. It is speculated that its mechanism of action may be embedded in DNA and confirmed by Foye’s experiments that it can bind to DNA and RNA. But Alberts et al. proved it again with L1210 cells.