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目的：研究乳腺癌组织人表皮生长因子受体－2（ HER－2）和基质金属蛋白酶－9（MMP－9）表达状况及与临床病理参数之间关系。方法收集我院100例乳腺癌组织，用免疫组化法检测其HER－2和MMP－9蛋白的表达，结合临床病理资料，分析其与临床病理特征之间的关系及两者的相关性。结果100例乳腺癌患者中， HER －2和 MMP －9阳性表达率分别为52．00％（52／100），71．00％（71／100）；雌激素受体（ ER）和孕激素受体（ PR）阳性率分别为54．00％（54／100），52．00％（52／100）；HER－2和MMP－9表达与乳腺癌患者淋巴结转移、癌国际临床病理分期（TNM）分期、ER和PR表达相关（均P＜0．05）；而与肿瘤直径、组织学分级差异无统计学意义（均P＞0．05），且与HER－2和MMP－9表达无明显相关性（P＞0．05）。结论联合检测HER－2和MMP－9对乳腺癌的淋巴结转移、临床治疗及预后判断具有非常重要的意义。“,”Objective To investigate the expression of human epidermal growth factor receptor -2 ( HER -2 ) and matrix metalloproteinase -9 ( MMP-9) gene in breast cancer, and analyze the relationship between HER-2 and MMP-9 and clinical pa-thology.Methods The expre-ssion of HER-2 and MMP-9 in breast cancer tissues(100 cases) were selected and examined by immunohistochemical method. The clinical pathological features and the relationship were analyzed.Results Posi-tive expression rates of HER -2 and MMP -9 in 100 cases of breast cancer were 52.00%(52/100) and 71.00%(71/100).Positive expre-ssion rates of estrogen receptor ( ER ) and progesterone receptor ( PR ) were 54.00%( 54/100 ) and 52.00%( 52/100 ) .The expression of HER-2 and MMP -9 had correlation with lymph node metastasis, tumor, node, metastasis cassification ( TNM ) stage, ER and PR expre-ssion(P0.05 ) . Furthermore, there was no correlation between the expression of HER-2 and MMP-9(P>0.05).Conclusion Combined detection of HER-2 and MMP -9 is of great importance in the predicting the lymph node metastasis, prognosis judgement and clinical comprehensive treatments.