论文部分内容阅读
探讨老年人微小病变性(MC)特发性肾病综合征(PNS)的临床特征及预后。方法 观察成人MC性PNS118例,其中老年患者18例,占15.2％。结果 发现老年患者NS的临床表现与成年组相似;但血尿发病率较低,22％比38％;高血压和肾功能不全的发病率明显增高,38.9％比16％和33.3％比19％(P<0.01)。老年组对激素治疗的敏感性略差;但NS复发率明显减少,11.1％比43％。结论 尽管NS的复发和对激素依赖使治疗有一定困难,但激素、细胞毒性药物和环孢素A对于消除蛋白尿,延缓肾功能不全是有助的。
To investigate the clinical features and prognosis of idiopathic nephrotic syndrome (PNS) in the elderly with minimal disease (MC). Methods One hundred and eighty eight cases of adult PNS were observed, including 18 elderly patients (15.2%). Results showed that the clinical manifestations of NS in elderly patients were similar to those in the adult group; however, the incidence of hematuria was lower at 22% to 38%; the incidence of hypertension and renal insufficiency was significantly higher with 38.9% vs 16% and 33.3% vs 19% P <0.01). The sensitivity of the elderly group to hormone therapy is slightly worse; but the NS recurrence rate was significantly reduced, 11.1% vs 43%. Conclusion Although NS recurrence and hormone-dependent treatment have some difficulties, hormones, cytotoxic drugs and cyclosporin A are helpful to eliminate proteinuria and delay renal insufficiency.