目的：观察白花前胡甲素对豚鼠心肌细胞电生理特性的影响，以探讨其抗心律失常的作用机制。方法：实验采用标准玻璃微电极技术。结果：ＰｄⅠａ对豚鼠心肌细胞的动作电位时程（ＡＰＤ）及慢反应动作电位时程均有缩短作用，ＰｄⅠａ还使慢反应动作电位的振幅（ＡＰＡ）明显减小，两者均呈现剂量依赖关系。结论：ＰｄⅠａ的抗心律失常作用，可能与阻滞钙离子内流、阻断钙通道的作用有关 Objective: To observe the effect of prestatin on the electrophysiological properties of guinea pig cardiomyocytes in order to investigate its anti-arrhythmic mechanism. Methods: The experiment using standard glass microelectrode technology. Results: PdⅠa shortened the action potential duration (APD) and slow response action potential duration of guinea pig cardiomyocytes, and PdⅠa also significantly decreased the APA of slow response action potentials, both Showing a dose-dependent relationship. Conclusion: The anti-arrhythmic effect of Pd-Ⅰa may be related to the effect of blocking calcium influx and blocking calcium channel