在抑癌基因中,p53与肿瘤的关系较早受到人们的重视,而且是迄今研究的最为广泛、最为系统的抗癌基因之一。p53非热点区的突变形成人群的多态性。越来越多的研究表明,位于第4外显子codon72的多态性与多种肿瘤易感性、治疗及预后存在相关性。本文就这一方面的研究做一简要综述。并对以后p53codon72多态性的研究方向提出一些建议。 Among the tumor suppressor genes, the relationship between p53 and tumor has attracted people’s attention earlier, and it is one of the most extensive and most systematic anti-cancer genes studied so far. Mutations in p53 non-hot spot regions lead to population polymorphism. More and more studies have shown that there is a correlation between the polymorphism of codon72 located in exon 4 and various tumor susceptibility, treatment and prognosis. This article gives a brief overview of this aspect of research. And made some suggestions on the future research direction of p53codon72 polymorphism.