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目的:探讨慢性阻塞性肺疾病(COPD)急性加重期患者血液凝血功能相关指标的改变及其临床意义。方法:比较COPD急性加重期(AECOPD)(研究组,n=82)及健康体检者(对照组,n=36)的纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及D-二聚体(D-D)的差异。结果:研究组APTT(46.1±9.7)s、FIB(5.0±1.8)g/L、D-D(463.2±185.3)ug/L均明显高于对照组的(31.1±4.3)s、(2.9±1.1)g/L、(81.1±33.2)ug/L,P均<0.05;而TT、PT在两组问无明显差异(P>0.05)。结论:AECOPD患者存在明显高凝状态,需要抗凝干预治疗。
Objective: To investigate the changes of blood coagulation related indexes in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its clinical significance. METHODS: Fibrinogen (FIB), prothrombin time (PT), activated partial thromboplastin (ACI), blood pressure and blood pressure were compared between AECOPD (study group, n = 82) and healthy subjects (control group, n = 36) (APTT), thrombin time (TT) and D-dimer (DD). Results: The APTT (46.1 ± 9.7) s, FIB (5.0 ± 1.8) g / L and DD (463.2 ± 185.3) ug / L in the study group were significantly higher than those in the control group (31.1 ± 4.3) s and (2.9 ± 1.1) g / L, (81.1 ± 33.2) ug / L, P <0.05, while TT and PT had no significant difference between the two groups (P> 0.05). Conclusion: AECOPD patients have obvious hypercoagulable state, need anticoagulant intervention.