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目的探讨细辛脑注射液、布地奈德混悬液交替氧气驱动雾化吸入治疗毛细支气管炎的疗效。方法 120例毛细支气管炎患儿随机分为治疗组(A、B组)与对照组各40例;A组:布地奈德混悬液1mg(2ml)/次,2次/d。B组:布地奈德混悬液1mg(2ml)/次,2次/d;细辛脑按0.5mg/(kg.次),加入生理盐水2ml,2次/d;二药间隔6h交替。对照组:α-糜蛋白酶5mg/次及地塞米松1～2mg/次,2次/d。连用5～7d,观察各组咳嗽、喘憋、气促、哮鸣音和湿啰音好转情况及不良反应。结果临床疗效比较,A组高于对照组,但差异无统计学意义,B组高于对照组,差异有统计学意义;喘憋、哮鸣音消失时间及平均住院时间治疗组与对照组比较明显缩短,差异均有统计学意义。结论细辛脑注射液、布地奈德混悬液交替氧气驱动雾化吸入治疗毛细支气管炎能增强疗效,迅速缓解症状,缩短病程,提高治愈率,且安全、简便。
Objective To investigate the therapeutic effect of Asarium Injection and Budesonide suspension alternating aerosol inhalation on bronchiolitis. Methods A total of 120 children with bronchiolitis were randomly divided into treatment group (A, B group) and control group (40 cases each). Group A: Budesonide suspension 1mg (2ml) / time, twice a day. Group B: budesonide suspension 1mg (2ml) / time, 2 times / d; asarone 0.5mg / (kg. Times), added to normal saline 2ml, 2 times / d; Control group: α-chymotrypsin 5mg / time and dexamethasone 1 ~ 2mg / time, 2 times / d. Used 5 ~ 7d, observed in each group cough, wheezing, shortness of breath, wheezing and wet rales improved situation and adverse reactions. Results Clinical efficacy comparison, A group was higher than the control group, but the difference was not statistically significant, B group was higher than the control group, the difference was statistically significant; wheezing, wheeze disappear time and average hospital stay treatment group compared with the control group Significantly shorter, the differences were statistically significant. Conclusions Asarone injection and budesonide suspension alternately aerosol inhalation treatment of bronchiolitis can enhance the curative effect, quickly relieve symptoms, shorten the course of disease and improve the cure rate, and it is safe and easy.