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采用心脏程序刺激方法和单相动作电位记录技术研究静脉注射氯卡胺(2mg/kg)对12例房室折返心动过速患者右室肌复极化过程的影响。每例患者测定给药前后右室肌有效不应期和记录固定右房起搏频率(120ppm)时右室肌单相动作电位。结果显示氯卡胺明显缩短单相动作电位复极化90%、50%间期(MAPD_(90)、MAPD_(50)),加速心室肌复极化过程;心肌有效不应期改变不明显,右室有效不应期与MAPD_(90)比值显著增加,由此提示氯卡胺可增加心肌的膜稳定性。
The effects of intravenous amlodipine (2 mg / kg) on the process of right ventricular repolarization in 12 patients with atrioventricular tachycardia were studied using cardiac program stimulation and monophasic action potential recording technique. Each patient was measured before and after administration of RV effective refractory period and fixed right atrial pacing frequency (120ppm) when the right ventricular single-phase action potential. The results showed that clofacamine significantly shortened the 90%, 50% (MAPD_ (90), MAP_ (50)) of single phase action potentials and accelerated the process of ventricular repolarization. The effective refractory period of myocardium did not change obviously, Right ventricular effective refractory period and the MAPD_ (90) ratio was significantly increased, suggesting that beclometamine can increase myocardial membrane stability.