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目的探讨胰岛素抵抗、高胰岛素血症及胰岛β细胞功能与老年高血压病的关系。方法 87例老年原发性高血压病患者依据体质量指数分为单纯高血压病组(A组)和高血压病合并肥胖组(B组),并选择同期体检健康者45例为对照组(C组),检测3组血脂、血尿酸、血清胰岛素及C肽水平,计算胰岛素抵抗指数、胰岛β细胞功能指数、胰岛素敏感指数值,并进行比较。结果 A,B组患者血脂水平、血尿酸水平、血清胰岛素、C肽水平及胰岛素抵抗指数、胰岛β细胞功能指数高于C组(P<0.05),胰岛素敏感指数低于C组(P<0.01);上述指标B组与A组比较差异均有统计学意义(P<0.05)。结论胰岛素抵抗是老年高血压病重要危险因素之一。
Objective To investigate the relationship between insulin resistance, hyperinsulinemia and pancreatic β-cell function in elderly patients with essential hypertension. Methods Eighty-seven elderly patients with essential hypertension were divided into simple hypertension group (A group) and hypertension complicated with obesity group (B group) according to body mass index, and 45 healthy subjects were selected as the control group Group C). The levels of serum lipids, serum uric acid, serum insulin and C-peptide in the three groups were measured and insulin resistance index, beta cell function index and insulin sensitivity index were calculated and compared. Results The blood lipid level, serum uric acid level, serum insulin, C-peptide level and insulin resistance index and pancreatic β-cell function index in group A and B were higher than those in group C (P <0.05) ); There was significant difference between group B and group A (P <0.05). Conclusion Insulin resistance is one of the important risk factors of hypertension in elderly.