一、前言虽然分子药理学的研究发展迅速,但对抗血吸虫药的定量或半定量构效关系迄今报导很少.严汉英等发现溴乙酸香豆素酯衍生物对抗血吸虫作用有程度不同的生物活性,王锐等新近也报导了他们所合成的类似物,但均未作构效关系的研究.本文用HMO·法计算溴乙酸香豆素酯衍生物的分子轨道指数,探索抗血吸虫活性与分子轨道指数之间的 I. Preface Although the rapid development of molecular pharmacology, but quantitative or semi-quantitative structure-activity relationship against schistosomiasis so far reported.Han Han-ying and other found that coumarin bromoacetate derivatives have different degrees of biological activity against schistosomiasis, Wang Rui et al recently also reported their synthetic analogs, but none of the study of the relationship between structure-activity relationship.In this paper, the molecular weight index of coumarin bromoacetate derivatives was calculated by HMO method to explore the relationship between activity and molecular orbital Between indices