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目的:对4种国产、1种进口氧氟沙星进行体外溶出度的考察比较。方法:溶出度测定采用中国药典规定的转篮法。氧氟沙星含量采用紫外分光先度法,于294nm波长处测定,并进行日内变异和日间变异的考察。结果:国产4种片剂均符合中国药典1995版标准,30min溶出80％以上,国外产品30min溶出79％。结论:所测定的4种国产氧氟沙星片剂质量可靠。
OBJECTIVE: To investigate the in vitro dissolution of 4 domestic and 1 imported ofloxacin. Methods: Dissolution was determined by the Chinese Pharmacopoeia basket method. Ofloxacin content using UV spectrophotometry method, measured at 294nm wavelength, and intra-day variation and day-to-day variation of the inspection. Results: All four kinds of tablets in China were in accordance with the standard of Chinese Pharmacopoeia 1995 edition, with dissolution rate of more than 80% in 30 minutes and 79% in 30 minutes in foreign products. Conclusion: The four kinds of domesticloxacin tablets are of reliable quality.