我国是乙肝病毒感染的高发地区,接种乙肝疫苗是预防、阻断乙肝病毒感染最有效的方法。而接种后无应答者仍然是HBV的易感者。解决乙肝疫苗接种后的无应答问题,对控制人群HBV感染的发生非常重要[1]。目前,我国用于人群接种的乙肝疫苗均为基因重组疫苗。该疫苗主要分为酵母细胞和 China is a high incidence of hepatitis B virus infection, hepatitis B vaccine is to prevent, block the most effective method of hepatitis B virus infection. Non-responders after vaccination are still susceptible to HBV. To solve the problem of non-response after hepatitis B vaccination, it is very important to control the occurrence of HBV infection in the population [1]. Currently, hepatitis B vaccines used for population vaccination in China are all gene recombinant vaccines. The vaccine is divided into yeast cells and