论文部分内容阅读
为观察nm23－H_1基因产物和p53基因产物在鼻咽癌（NPC）的表达状态，探讨其与NPC的发生及转移、预后的关系。采用S－P免疫组织化学方法检测nm23－H_1基因产物和p53基因产物的表达。结果示nm23－H_1蛋白的表达率为50．4％，p53蛋白的表达率为90．4％。nm23－H_1蛋白在颈部有淋巴结转移包块者的表达率为27．9％，低于无颈部淋巴结转移包块者的表达率（71．9％），两者有非常显著性差异（P＜0．001）。nm23－H_1蛋白及p53蛋白的表达率分别与NPC的病理组织学分型和预后均无明显关系（P＞0．05）。提示p53蛋白的过表达与NPC的发生密切相关，nm23－H_1基因在抑制NPC的颈部淋巴结转移中有一定的作用。
To observe the expression of nm23-H 1 gene product and p53 gene product in nasopharyngeal carcinoma (NPC), and to explore the relationship between the expression of nm23-H 1 gene and the metastasis and prognosis of NPC. S-P immunohistochemistry was used to detect the expression of nm23-H 1 gene product and p53 gene product. The results showed that the expression of nm23-H 1 protein was 50.4%, the expression of p53 protein was 90.4%. The expression rate of nm23-H_1 protein was 27.9% in patients with lymph node metastasis on the neck, which was lower than that in the patients without lymph node metastasis (71.9%). There was a significant difference between the two P <0.001). The expression rates of nm23-H_1 protein and p53 protein had no significant correlation with the histopathological types and prognosis of NPC (P> 0.05). It is suggested that the overexpression of p53 protein is closely related to the occurrence of NPC. The nm23-H 1 gene may play a role in the suppression of NPC cervical lymph node metastasis.