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目的探讨肿瘤相关糖类抗原50(carbohydrate antigen,CA)、CA199和癌胚抗原(carcinoembryonic antigen,CEA)三项肿瘤标志物联合检测对胃肠道肿瘤的诊断价值。方法应用电化学发光法检测胃肠道肿瘤患者152例和健康对照组46例外周血血清CA50、CA199和CEA三项标志物。结果胃肠道肿瘤组CA50、CA199、CEA水平均高于对照组(P<0.05)。胃肠道肿瘤组三项指标联合检测敏感性为86.7%、诊断符合率80.8%均明显高于单项检测(P<0.05)。结论联合检测CA50、CA199和CEA,可以提高肿瘤标志物对胃肠道肿瘤的临床诊断价值。
Objective To investigate the diagnostic value of tumor associated carbohydrate antigen (CA), CA199 and carcinoembryonic antigen (CEA) combined detection of three tumor markers in gastrointestinal tumors. Methods Electrochemiluminescence was used to detect three markers of peripheral blood serum CA50, CA199 and CEA in 152 patients with gastrointestinal cancer and 46 healthy controls. Results The levels of CA50, CA199 and CEA in gastrointestinal cancer group were significantly higher than those in control group (P <0.05). Gastrointestinal tumor group combined detection of three indicators of sensitivity was 86.7%, diagnostic coincidence rate of 80.8% were significantly higher than the single test (P <0.05). Conclusion Combined detection of CA50, CA199 and CEA can improve the clinical diagnostic value of tumor markers in gastrointestinal tumors.