３０名健康自愿受试者，随机进入５个试验组，分别单剂口服国产盐酸芦氟沙星片５０、１００、２００、４００和６００ｍｇ后观察７２小时。结果显示，５０～２００ｍｇ组无任何不良反应；４００ｍｇ组可出现轻度恶心与上腹不适，但可耐受；６００ｍｇ组中３名受试者出现了轻至中度的恶心、上腹不适、呕吐、头痛、兴奋与失眠。本试验结果提示，芦氟沙星片日剂量在４００ｍｇ内耐受良好。 Thirty healthy volunteers were enrolled in five randomized trials and were given a single oral dose of 50, 100, 200, 400 and 600 mg of domestic homemade rufloxacin hydrochloride tablets for 72 hours. The results showed that 50 ~ 200mg group without any adverse reactions; 400mg group may appear mild nausea and abdominal discomfort, but tolerable; 600mg group of three subjects showed mild to moderate nausea, abdominal discomfort, Vomiting, headache, excitement and insomnia. The test results suggest that rufloxacin tablets daily dose of 400mg well tolerated.