A kind of active vibration control method was presented based on active damping and optimization design for driving load of multibody system with quick startup and brake. Dynamical equation of multibody system with quick startup and brake and piezoelectric actuators intelligent structure was built. The optimum driving load was calculated by applying the presented method. The self-sensing and self-tuning closed-loop active vibration control in quick startup and brake process was realized. The control algorithm, using local velocity negative feedback, i.e. the output of a sensor only affects the output of the actuator collocated, can induce damping effectively to actively suppress the system vibration. Based on the optimization design for driving load of multibody system with quick startup and bake, the active damping of piezoelectric actuators intelligent structure was used to farther suppress the vibration of system. Theoretical analysis and calculation of numerical show that the proposed method makes the vibration of system decrease more than the optimal design method for driving load of multibody system.