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ADAM33是一种新近发现的解整合素-金属蛋白酶(adistintegrin and metalloproteinase,ADAM)家族成员。部分研究认为,其基因多态性与气道高反应性和气道重塑相关,该基因突变表达后能够影响肺功能从而使之与哮喘产生强烈的相关性,而部分学者的研究后却并不认同这个观点,并且对于不同种族人群的ADAM33和哮喘的关系的研究中得出了许多不一致的结论。该文就这两种意见进行综述,以便能更全面地了解ADAM33基因的功能及其对支气管哮喘的作用,有助于从新的角度研究支气管哮喘的发病机制。
ADAM33 is a newly discovered member of the ADAM family of ADAMs. Some studies suggest that the gene polymorphism associated with airway hyperresponsiveness and airway remodeling, the gene expression can affect the lung function so that it has a strong correlation with asthma, and some scholars did not Agree with this view, and draw many inconsistent conclusions about the relationship between ADAM33 and asthma in different ethnic groups. This review summarizes these two opinions in order to provide a more complete understanding of ADAM33 gene function and its role in bronchial asthma and help to study the pathogenesis of bronchial asthma from a new perspective.