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补体是一个由近40个蛋白分子组成的多级连续的有限蛋白解(limited proteolysis)级联反应系统.所谓有限蛋白解是指特异的蛋白酶在补体蛋白特异部位将该分子或其活性分段进行切割而不继续裂解为更小的肽段或氨基酸.这样裂出的肽段就是补体的活性分段,分别执行补体的各种功能,构成免疫学应答的重要环节.要进行蛋白解,就需要蛋白酶.在补体系统中共有6个蛋白酶参与有限蛋白解,他们是Clr、Cls、C2、B因子(Bf)、D因子(D)及I因子(I).这几个酶的结构功能有下列特点.
Complement is a multi-level continuous cascade of limited proteolysis cascade reaction system consisting of nearly 40 protein molecules, which means that a specific protease fragments the molecule or its activity in specific parts of the complement protein Cutting and not continue to split into smaller peptides or amino acids. The cleaved peptide is the activity of the complement of the fragment, respectively, perform various functions of complement, immunological response constitutes an important part of the proteolytic solution, you need There are six proteases involved in the limited proteolysis in the complement system, they are Clr, Cls, C2, B (Bf), D (D) and I. The structural functions of these enzymes are as follows Features.