B细胞抗原受体(B cell antigen receptor,BCR)表达密度在未成熟B细胞向成熟亚群分化的过程中有重要作用,然而,其影响天然自身反应性B细胞发育的具体方式还不清楚在本课题中,我们研究了来源于天然多反应性自身抗体3B4的转基因小鼠,分析了两系不同免疫球蛋白重链转基因拷贝数转基因小鼠中BCR表面密度与自身反应性B细胞发育的关系。我们发现,在转基因小鼠中BCR表达水平和转基因拷贝数成正比。在转基因拷 The expression density of B cell antigen receptor (BCR) plays an important role in the differentiation of immature B cells into mature subgroups. However, the specific way of affecting the development of natural autoreactive B cells is unclear. In this study, we investigated transgenic mice derived from natural multi-reactive autoantibody 3B4 and analyzed the relationship between BCR surface density and autoreactive B cell development in two-line different immunoglobulin heavy chain transgenic copy number transgenic mice . We found that the level of BCR expression in transgenic mice is directly proportional to the number of transgene copies. Transgenic copy