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目的：探讨碱性成纤维细胞生长因子 ( bFGF )表达、肿瘤血管形成在垂体腺瘤侵袭性中的意义. 方法：用免疫组化法(SABC法)检测 39例侵袭性垂体腺瘤、19例非侵袭性垂体腺瘤和4例正常垂体腺组织中 bFGF的表达,并用第Ⅷ因子相关抗原(F8-RA)免疫组化染色来计数垂体腺瘤的血管数量(微血管密度),探讨二者与肿瘤侵袭性的关系. 结果：bFGF的表达、肿瘤血管形成与垂体腺瘤的侵袭性密切相关.侵袭性垂体腺瘤bFGF表达水平、血管计数显著高于非侵袭性垂体腺瘤和正常垂体腺组织,而非侵袭性垂体腺瘤与正常腺组织间则无显著差异(t=1.469,P>0.05)；侵袭性腺瘤中bFGF表达水平与肿瘤微血管数量呈正相关(r=0.361,P<0.05). 结论：bFGF可能通过促血管生成作用刺激垂体腺瘤生长与侵袭.
Objective: To explore the significance of basic fibroblast growth factor (bFGF) expression and tumor angiogenesis in the invasion of pituitary adenomas. Methods: 39 cases of invasive pituitary adenomas were detected by immunohistochemical method (SABC method). Expression of bFGF in non-invasive pituitary adenomas and 4 normal pituitary glands. Immunohistochemical staining of factor VIII-associated antigen (F8-RA) was used to count the number of blood vessels (microvessel density) in pituitary adenomas. Relationship between tumor invasiveness. Results: The expression of bFGF and the formation of tumor blood vessels are closely related to the invasiveness of pituitary adenomas. The expression of bFGF and the blood vessel counts of invasive pituitary adenomas are significantly higher than those of non-invasive pituitary adenomas and normal pituitary glands. There was no significant difference between non-invasive pituitary adenoma and normal gland tissue (t=1.469, P>0.05). The expression of bFGF was positively correlated with the number of tumor microvessels in invasive adenoma (r=0.361, P<0.05). Conclusion: bFGF may stimulate the growth and invasion of pituitary adenomas by promoting angiogenesis.