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目的：探讨应用灯盏花注射液治疗原发性干燥综合征（PSS）的机理及疗效。方法：治疗组45例PSS患者，用灯盏花注射液20ml加入生理盐水250ml静点，1次／日，14d为一疗程；同时用复方丹参注射液作对照组。治疗前后在检查泪腺分泌功能和居腺活检的基础上，还检测患者的甲镇微循环及免疫球蛋白的变化。结果：治疗组总有效率95．6％，对照组16．7％。治疗后患者甲皱微循环明显改善，免疫球蛋白恢复正常。结论：灯盏花注射液的主要成分为飞蓬甙、黄芩素甙等9种成分。主要功能有降低血粘度，对抗血小板和血细胞聚集，抗内凝血及促进纤维蛋白原的溶解，改善微循环，调节免疫和促进外分泌腺的分泌作用。治疗PSS有显著疗效，值得在临床上进一步推广应用。
Objective: To investigate the mechanism and efficacy of Erigeron Injection in the treatment of primary Sjogren’s Syndrome (PSS). Methods: The treatment group of 45 patients with PSS, with Erigeron Injection 20ml saline 250ml static point, 1 time / day, 14d for a course of treatment; at the same time with compound Danshen injection as a control group. Before and after the treatment of lacrimal gland secretion in the inspection and gland biopsy on the basis of the test, but also test the patient’s town microcirculation and immunoglobulin changes. Results: The total effective rate was 95.6% in the treatment group and 16.7% in the control group. After treatment, patients with nail fold microcirculation improved significantly, immunoglobulin returned to normal. Conclusion: The main components of Erigeron Injection is phlepin, baicalein and other 9 components. The main function is to reduce blood viscosity, anti-platelet and blood cell aggregation, anti-coagulation and promote the dissolution of fibrinogen, improve microcirculation, regulate immunity and promote secretion of exocrine glands. Treatment of PSS has a significant effect, it is worth further promotion in clinical application.