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为探讨大肠癌血管生成与肝脏转移的关系。采用免疫组织化学方法检测了 2 8例有肝脏转移和 30例无肝脏转移的原发性大肠癌石蜡标本中的微血管密度。结果 ,光镜下 ,2 0 0倍视野计数微血管密度 ,肝脏转移组为 (36 2± 1 1 3)个 ,显著高于无肝脏转移组的 (31 8± 1 1 5)个 ;35例侵犯静脉者肝脏转移为 2 2例 ,转移率高于 2 3例未侵犯静脉的 6例。结果提示 ,原发性大肠癌组织中的微血管密度与肿瘤的转移行为密切相关 ,可能成为判断肿瘤转移及预后的指标
To investigate the relationship between angiogenesis and hepatic metastasis in colorectal cancer. Immunohistochemistry was used to detect microvessel density in 28 cases of primary colorectal cancer with liver metastases and 30 cases of non-hepatic metastases. Results: Under the light microscope, the microvessel density in the field of 200 times visual field was (36 2 ± 1 1 3) in liver metastasis group, which was significantly higher than that in non-liver metastasis group (31 8 ± 1 1 5) Venous liver metastases were 22 cases, the transfer rate was higher than 23 cases of noninvasive vein in 6 cases. The results suggest that the microvessel density in primary colorectal cancer is closely related to tumor metastasis and may be an indicator of tumor metastasis and prognosis