在急性感染和传统感染模式中,宿主利用固有免疫机制应对一系列病原体的入侵。然而,一些病原菌可以成功逃避、抑制或颠覆免疫检测、信号转导或有效杀伤。该文就病原菌如何操纵宿主细胞的防御功能,调节胞内杀伤、信号转导,破坏固有免疫系统受体间分子信号的交联作用,并最终使微生物在宿主体内适应性生长、持续感染等方面作一综述。 In acute infections and traditional infection patterns, the host utilizes an innate immune mechanism to deal with the invasion of a range of pathogens. However, some pathogens can successfully escape, inhibit or subvert immunodetection, signal transduction, or effective killing. In this paper, how pathogen can manipulate the host cell’s defense function, regulate intracellular killing, signal transduction, destroy the cross-linking of molecular signals between innate immune system receptors and finally make the microorganisms grow adaptively in the host and continue to be infected Make a review