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目的:探讨Survivin和p53蛋白在非小细胞肺癌(NSCLC)组织中的表达及其临床意义。方法:采用免疫组化SP法检测60例NSCLC和10例肺良性病变组织中Survivin和p53蛋白的表达。结果:NSCLC组织中Survivin蛋白阳性表达率为61.6%,明显高于正常对照组的0,χ2=13.08,P=0.000。Sur-vivin蛋白在临床Ⅲ~Ⅳ期的阳性表达率为77.1%,显著高于Ⅰ~Ⅱ期的40.0%,χ2=8.511,P=0.004;而与性别、年龄以及病理类型等无明显关系,P>0.05。NSCLC组织中p53蛋白阳性表达率为56.7%,明显高于正常对照组的0,χ2=11.02,P=0.001。p53蛋白在临床Ⅲ~Ⅳ期的阳性表达率为71.4%,显著高于Ⅰ~Ⅱ期的36.0%,χ2=7.454,P=0.006;而与性别、年龄以及病理类型等无明显关系,P>0.05。结论:联合检测Survivin和p53蛋白可提高肺癌的早期诊断率,对判断病情及预后有重要临床意义。
Objective: To investigate the expression of Survivin and p53 protein in non-small cell lung cancer (NSCLC) and its clinical significance. Methods: Survivin and p53 protein expressions in 60 NSCLC specimens and 10 benign lesions of the lung were detected by immunohistochemical SP method. Results: The positive rate of Survivin protein expression in NSCLC was 61.6%, which was significantly higher than that in the normal control group (χ2 = 13.08, P = 0.000). The positive expression rate of Sur-vivin protein in clinical stage Ⅲ ~ Ⅳ was 77.1%, which was significantly higher than that in stage Ⅰ ~ Ⅱ 40.0%, χ2 = 8.511, P = 0.004, but not with sex, age and pathological type, P> 0.05. The positive expression rate of p53 protein in NSCLC tissues was 56.7%, which was significantly higher than that in the normal control group (χ2 = 11.02, P = 0.001). The positive expression rate of p53 protein in clinical stage Ⅲ ~ Ⅳ was 71.4%, which was significantly higher than that in stage Ⅰ ~ Ⅱ 36.0%, χ2 = 7.454, P = 0.006, but not with the gender, age and pathological type, P> 0.05. Conclusion: The combined detection of Survivin and p53 protein can improve the early diagnosis of lung cancer, which has important clinical significance in judging the disease and prognosis.