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目的探讨柯萨奇B组病毒（CoXB）感染和抗心肌线粒体抗体在扩张型心肌病发病中的作用。方法扩张型心肌病患儿30例，男19例，女11例，健康对照组40例，男女各20例。抗CoxBIgM抗体及抗心肌线粒体抗体测定采用酶联免疫法。结果扩张型心肌病患儿血清抗CoxBIgM抗体和抗心肌线粒体抗体阳性率分别为36．7％和40％，均显著高于对照组（阳性率分别为7．5％和0）。结论柯萨奇病毒感染及抗心肌线粒体抗体在部分扩张型心肌病的发病中起一定作用。
Objective To investigate the role of coxsackie B virus (CoXB) infection and anti-myocardial mitochondrial antibodies in the pathogenesis of dilated cardiomyopathy. Methods Thirty children with dilated cardiomyopathy were enrolled, including 19 males and 11 females, 40 healthy controls and 20 males and 20 females. Anti-CoxBIgM antibodies and anti-myocardial mitochondrial antibodies using enzyme-linked immunosorbent assay. Results The positive rates of anti-CoxBIgM antibody and anti-myocardial mitochondrial antibody in children with dilated cardiomyopathy were 36.7% and 40%, respectively, which were significantly higher than those in the control group (positive rates were 7.5% and 0% respectively). Conclusion Coxsackie virus infection and anti-myocardial mitochondrial antibodies play a role in the pathogenesis of partial dilated cardiomyopathy.