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Survivin即生存素,其基因由效应蛋白酶受体EPR-1(effector cell protease receptor 1)cDNA在人类基因库杂交筛选中分离出来,定位于人类染色体17q25区,全长14.7kb,由三个内含子和四个外显子组成,编码142个氨基酸。Survivin和EPR-1位于同一基因簇,并呈反向互补。Survivin蛋白是一种核穿梭蛋白,主要位于细胞质,在分裂间期它和胞质中心体位于同一区域,在有丝分裂时移动到着丝点与微管连接,最后在分裂末期定位到纺锤体。Survivin具有和其它IAP成员不同的独特的形态结构,仅含有一个相对保守的杆状病毒凋亡抑制蛋白
Survivin, a survivin gene, was isolated from the cDNA library of human effector cell protease receptor 1 (EPR-1) and located in the human chromosome 17q25 region with a full-length of 14.7 kb. Son and four exons, encoding 142 amino acids. Survivin and EPR-1 are located in the same gene cluster and reversely complementary. Survivin is a nuclear shuttle protein mainly located in the cytoplasm. It is located in the same region as the cytoplasmic centrosome during the interphase. It migrates to the centromere and then connects with the microtubules during mitosis, and finally to the spindle at the end of division. Survivin has a unique morphological structure that is different from other IAP members and contains only one relatively conserved baculovirus inhibitor of apoptosis protein