论文部分内容阅读
目的探讨十一种常用抗生素在体外环境中对血清肿瘤标志物含量的影响。方法 50份肿瘤患者血清和20份正常血清中分别加入11种常用抗生素,采用免疫化学发光法检测AFP、CEA、CA125、CA153和CA199五种肿瘤标志物前后含量的变化,采用T检验进行统计学分析。结果加入青霉素钠、阿昔洛韦、乳酸环丙沙星氯化钠、头孢他啶、头孢呋辛钠、奥硝唑片、头孢拉啶后AFP检测值有差异(P<0.05);在加入乳酸环丙沙星氯化钠、头孢他啶、头孢呋辛钠、头孢拉啶、阿奇霉素磷酸二氢钠后CEA检测值有差异(P<0.05);在加入阿昔洛韦、头孢呋辛钠、头孢拉啶、亚胺培南西司他丁钠后CA125检测值有差异(P<0.05);在加入青霉素钠、头孢呋辛钠、哌拉西林钠舒巴坦钠(2∶1)、奥硝唑片、阿昔洛韦后CA199检测值有差异(P<0.05);在加入青霉素钠、头孢呋辛钠、哌拉西林钠舒巴坦钠(2∶1)、奥硝唑片、亚胺培南西司他丁钠、头孢他啶后CA153检测值有差异(P<0.05)。结论 11种常用抗生素除硫酸庆大霉素外,绝大多数对肿瘤标志物检测有影响,排除药物干扰因素对提高肿瘤标志物检测准确性具有临床意义。
Objective To investigate the effect of eleven commonly used antibiotics on serum tumor markers in vitro. Methods Eleven commonly used antibiotics were added to sera of 50 cancer patients and 20 normal serum respectively. The levels of five tumor markers AFP, CEA, CA125, CA153 and CA199 were detected by immunochemical chemiluminescence before and after treatment. The T test was used for statistical analysis analysis. Results The AFP values of penicillin sodium, aciclovir, ciprofloxacin sodium chloride, ceftazidime, cefuroxime sodium, ornidazole tablets and cefradine were significantly different (P <0.05) The differences were significant (P <0.05) between the concentrations of ciprofloxacin sodium chloride, ceftazidime, cefuroxime sodium, cefradine, and azithromycin monobasic sodium phosphate. After adding acyclovir, cefuroxime sodium, cefradine (P <0.05). After the addition of penicillin sodium, cefuroxime sodium, piperacillin sodium and sulbactam sodium (2:1), ornidazole tablets, After acyclovir CA199 test values ?? were different (P <0.05); penicillin sodium, cefuroxime sodium, piperacillin sodium and sulbactam sodium (2: 1), ornidazole tablets, imipenem West Division The differences of CA153 between sodium and ceftazidime were significant (P <0.05). Conclusion The 11 most common antibiotics except gentamicin sulfate, the vast majority of tumor markers have an impact on the exclusion of drug interference factors to improve the accuracy of detection of tumor markers of clinical significance.