论文部分内容阅读
目的探讨二甲双胍联合格列美脲治疗2型糖尿病的临床疗效。方法收集我院2012年12月至2013年12月诊治的2型糖尿病患者220例作为研究对象,以抛硬币的方式分为试验组与对照组,每组各110例。对照组患者单纯采用二甲双胍治疗,试验组采用二甲双胍联合格列美脲治疗,对两组患者的治疗效果进行分析对比。结果研究结果显示,两组患者治疗前HbA1c和全天胰岛素用量比较,差异无统计学意义(P>0.05),经治疗后均得到明显改善,且试验组改善水平明显优于对照组(P<0.05)。试验组不良反应发生率为21.8%;对照组不良反应发生率为22.7%,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论二甲双胍联合格列美脲治疗2型糖尿病具有良好的临床疗效,且不会增加不良反应。
Objective To investigate the clinical efficacy of metformin combined with glimepiride in the treatment of type 2 diabetes mellitus. Methods A total of 220 type 2 diabetic patients diagnosed and treated in our hospital from December 2012 to December 2013 were selected as research objects, and were divided into experimental group and control group by coin tossing method, with 110 cases in each group. Patients in the control group were treated with metformin only. Patients in the test group were treated with metformin and glimepiride. The therapeutic effects of the two groups were compared and analyzed. Results The results showed that there was no significant difference in HbA1c dosage and insulin dosage before and after treatment between the two groups (P> 0.05), and the levels of HbA1c before and after treatment were significantly improved. The improvement in the experimental group was significantly better than that in the control group (P < 0.05). The incidence of adverse reactions in the experimental group was 21.8%. The incidence of adverse reactions in the control group was 22.7%. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Metformin combined with glimepiride has good clinical efficacy in the treatment of type 2 diabetes mellitus without any adverse reactions.