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最近以斑片电压钳位术(patch clamping)研究单个钙通道,以配合结合研究钙拮抗剂“受体位点”和新的钙通道激动剂的引入,使人们更加深入地理解了这些药物对钙通道作用的机制。业已证明,这些钙通道调节剂是如何与结合位点相互作用以影响钙流量,从而调节许多可兴奋组织的活动。
The recent study of single calcium channels by patch clamping in conjunction with the study of the “receptor sites” of calcium antagonists and the introduction of new calcium channel agonists has led to a deeper understanding of these drug pairs Mechanism of calcium channel action. It has been demonstrated how these calcium channel modulators interact with binding sites to affect calcium flux and thereby regulate the activity of many excitable tissues.