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位于质膜上的血小板源生长因子ＰＤＧＦ特异性受体是生长因子ＰＤＧＦ携带的信息跨膜向细胞内传递的关键环节。此种具酪氨酸蛋白激酶活性的受体在ＰＤＧＦ激活的生长调节中通过对多种靶蛋白磷酸化实现对增殖的调节作用。与ＰＤＧＦ相关的多种疾病的发生、发展过程中均出现相应的ＰＤＧＦ受体的改变。受体水平的调节可能有利于缓解与ＰＤＧＦ密切相关的过度增殖性疾病。
Platelet-derived growth factor PDGF-specific receptors located on the plasma membrane are key components of the transmembrane-to-intracellular transmission of the growth factor PDGF. Such tyrosine kinase-active receptors regulate the proliferation in PDGF-activated growth regulation by phosphorylating multiple target proteins. A variety of PDGF-related diseases occur during the development of the corresponding PDGF receptor changes. Regulation of receptor levels may help to alleviate the hyperproliferative diseases closely related to PDGF.