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目的:观察中西医结合治疗咳嗽变异性哮喘(CVA)的临床疗效,及对患者血清炎症因子的影响。方法:将78例CVA患者随机分为中西医组和西医组各39例。西医组给予沙美特罗/丙酸氟替卡松吸入加孟鲁司特咀嚼片口服治疗,中西医组在西医组用药基础上联合麻杏石甘汤加味治疗,2组均治疗8周。观察2组治疗前后血清白细胞介素(IL)-4与IL-10水平的变化,并比较临床疗效。结果:治疗前,2组血清IL-4与IL-10水平比较,差异均无统计学意义(P>0.05)。治疗后,2组IL-4水平均较治疗前下降(P<0.05,P<0.01),IL-10水平均较治疗前上升(P<0.05,P<0.01);中西医组IL-4水平低于西医组(P<0.05),IL-10水平高于西医组(P<0.05)。中西医组总有效率(94.87%)高于西医组(79.49%),差异有统计学意义(P<0.05)。结论:在沙美特罗/丙酸氟替卡松合孟鲁司特咀嚼片治疗CVA的基础上加麻杏石甘汤加味,能有效改善患者的IL-4及IL-10水平,提高临床疗效。
Objective: To observe the clinical curative effect of combining traditional Chinese and western medicine on cough variant asthma (CVA) and its effect on serum inflammatory factors. Methods: A total of 78 patients with CVA were randomly divided into two groups: 39 cases in the Western and Western medicine groups. Western medicine group received salmeterol / fluticasone propionate inhalation plus montelukast chewable tablet oral treatment, Western medicine group based on the Western medicine group combined with Maxing Shigan Decoction treatment, two groups were treated for 8 weeks. The changes of serum interleukin (IL) -4 and IL-10 levels before and after treatment in both groups were observed, and the clinical effects were compared. Results: Before treatment, the levels of IL-4 and IL-10 in two groups had no significant difference (P> 0.05). The levels of IL-4 in both groups were significantly lower than those before treatment (P <0.05, P <0.01) Lower than western medicine group (P <0.05), IL-10 level higher than Western medicine group (P <0.05). The total effective rate of Chinese and Western medicine group (94.87%) was higher than Western medicine group (79.49%), the difference was statistically significant (P <0.05). Conclusion: Salmeterol / propofol montelukast chewable tablets on the basis of the treatment of CVA plus Maxingshigan Decoction, can effectively improve the level of IL-4 and IL-10 in patients with improved clinical efficacy.