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目的:探讨婴儿高间接胆红素血症时肝功能及心肌酶学的变化。方法:观察组139例高间接胆红素血症足月婴儿,对照组55例同期非高胆红素血症婴儿,对其血清天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、α-羟丁酸脱氢酶(α-HBD)、肌酸激酶同功酶(CK-MB)、总胆红素(TBil)、直接胆红素(DBil)检测结果进行回顾性分析。结果:与对照组比较,观察组血清AST、LDH、CK、α-HBD、CK-MB升高具有显著性差异(P<0.01)。结论:婴儿高胆血症对心脏具有损伤作用,临床上在积极控制高胆血症,防止核黄疸发生的同时,应积极监测患儿心肌酶,并加强对心肌的营养及保护性治疗。
Objective: To investigate the changes of liver function and myocardial enzyme in infant with indirect hyperbilirubinemia. Methods: One hundred and ninety-three infants with full-term indirect hyperbilirubinemia in the observation group and 55 infants with non-hyperbilirubinemia in the control group were enrolled in this study. Serum levels of aspartate aminotransferase (AST), lactate dehydrogenase LDH, CK, α-HBD, CK-MB, TBil, DBil ) Test results for retrospective analysis. Results: Compared with the control group, the serum AST, LDH, CK, α-HBD and CK-MB in the observation group had significant difference (P <0.01). Conclusion: Infantile hypercholeremia has a damaging effect on the heart. Clinically, while actively controlling hypercholeremia and preventing the occurrence of nuclear jaundice, we should actively monitor myocardial enzymes in children and strengthen the nutrition and protective treatment of the myocardium.