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NO是一种由内源性L-精氨酸台成的内皮舒张因子。它通过抑制非肾上腺素能、非胆碱能神经(NANC),使血管及支气管平滑肌舒张。然而,它对肺内通气/血流比例(V_A/Q)的影响尚不清楚。作者对9头几内亚猪建立乙酰甲胆碱(MCH)诱导的支气管狭窄模型,分别观察吸入NO及特普他林(Terbutaline)对V_A/Q的影响。
NO is an endothelium derived from endogenous L-arginine. It inhibits vascular and bronchial smooth muscle relaxation by inhibiting non-adrenergic and non-cholinergic nerves (NANC). However, its impact on ventilatory / blood flow ratio (V_A / Q) in the lung is not clear. The authors established a methacholine (MCH) -induced bronchoconstriction model in 9 guinea pigs and observed the effects of inhaled NO and terbutaline on V_A / Q.