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为观察 Ｌ－ 精氨酸对家兔动脉粥样硬化斑块形成及血脂的影响，将４５ 只新西兰白兔随机分为正常组、对照组和治疗组，正常组用标准饲料喂养，对照组用含２ ．５ ％ 胆固醇的标准饲料及普通饮水喂养，治疗组用含２ ．５ ％ 胆固醇的标准饲料及含２ ．２５ ％ Ｌ－ 精氨酸的普通饮水喂养，７ 周及１４ 周时检测血清总胆固醇及甘油三酯，同时用油红 Ｏ 将升主动脉及降主动脉染色，利用图像分析仪计算动脉粥样硬化斑块面积百分比。结果发现，在实验第７ 周时治疗组的血脂明显低于对照组，但到实验第１４ 周时两组的血脂变化无统计学差异，且发现实验第７ 周和第１４ 周时治疗组升主动脉粥样硬化斑块面积较对照组也是前期明显减少，后期趋于一致，而治疗组降主动脉粥样硬化斑块面积始终明显少于对照组。结果提示，在防治动脉粥样硬化及降脂方面， Ｌ－ 精氨酸的长期疗效并不显著。
To observe the effect of L-arginine on atherosclerotic plaque formation and blood lipid in rabbits, 45 New Zealand white rabbits were randomly divided into normal group, control group and treatment group. Normal group was fed with standard diet and control group Contains 2 5% cholesterol standard feed and normal drinking water, treatment group containing 2. 5% cholesterol standard feed and containing 2. 25% L-arginine ordinary drinking water, serum total cholesterol and triglycerides were measured at 7 weeks and 14 weeks, and the ascending aorta and descending aorta were stained with oil red O, and atherosclerotic Sclerosis plaque area percentage. The results showed that at the seventh week of the experiment, the blood lipids in the treatment group were significantly lower than those in the control group, but there was no significant difference in the blood lipid levels between the two groups by the 14th week of the experiment. Aortic atherosclerotic plaque area is also significantly reduced compared with the control group, the latter tend to be consistent, and the treatment group, aortic atherosclerotic plaque area is always significantly less than the control group. The results suggest that in the prevention and treatment of atherosclerosis and lipid-lowering, long-term efficacy of L-arginine is not significant.