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目的 证实黄体酮对缺血再灌注性脑损伤的保护作用 ,并初步探讨其作用机制。方法 制作大鼠脑缺血再灌注模型 ,将大鼠随机分为 6组 :黄体酮 (progesterone ,PROG)预防用药组、PROG预防并治疗组、PROG治疗组、单纯缺血再灌注组、阳性和阴性对照组。分别检测缺血再灌注后脑组织H2 O、Na+ 、K+ 和Ca2 + 含量的变化。结果 PROG预防组和PROG预防并治疗组均能明显降低缺血后脑组织H2 O、Na+ 和Ca2 + 含量的作用 ,PROG治疗组也具有降低脑组织H2 O和Na+ 含量的作用。结论 PROG能降低缺血再灌注性脑损伤脑组织H2 O、Na+ 、Ca2 + 的含量 ,减轻脑水肿 ,从而发挥对缺血脑的保护作用。
Objective To verify the protective effect of progesterone on cerebral ischemia-reperfusion injury and to explore its mechanism. Methods The rat model of cerebral ischemia-reperfusion was established. The rats were randomly divided into 6 groups: prophylactic group treated with progesterone (PROG), PROG group treated with PROG, PROG treated group, ischemia-reperfusion group Negative control group. The levels of H2 O, Na +, K + and Ca2 + in brain tissue were detected after ischemia-reperfusion. Results Both PROG prophylaxis group and PROG prophylaxis and treatment group could significantly reduce the contents of H2 O, Na + and Ca2 + in the ischemic brain tissue. PROG treatment group also had the effect of reducing the content of H2 O and Na + in brain tissue. Conclusion PROG can reduce the contents of H2 O, Na + and Ca2 + in brain tissue of ischemic-reperfused brain injury and relieve cerebral edema, which can protect the ischemic brain.