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目的探讨子宫内膜间质肉瘤(ESS)的发病情况、临床分期、形态学特征和免疫表型特点。方法 2004年至2010年在南京江北人民医院和徐州市中心医院病理科观察到子宫体间质肿瘤2 791例,发现ESS 17例。对17例ESS的年龄、临床分期、分化程度和免疫表型进行回顾性分析。结果 17例ESS患者平均年龄为(47.0±10.6)岁,70.6%在临床Ⅰ期和Ⅱ期。14例(82.4%)为低级别ESS,3例(17.6%)为高级别或未分化ESS。17例均测定免疫组化标记物,雌激素受体(ER)阳性5例(29.4%),孕激素受体(PR)阳性9例(52.9%);表达CD10者10例(58.8%),表达p53者12例(70.6%)。结论本组ESS占同期子宫体间质肿瘤的0.61%,且大部分为低级别ESS。p53、CD10及ER、PR呈不同程度阳性表达。
Objective To investigate the incidence, clinical stage, morphological features and immunophenotype of endometrial stromal sarcoma (ESS). Methods A total of 2 791 cases of uterine interstitial tumor were observed in the Department of Pathology, Nanjing Jiangbei People’s Hospital and Xuzhou Central Hospital from 2004 to 2010. 17 cases of ESS were found. The age, clinical stage, differentiation degree and immunophenotype of 17 cases of ESS were analyzed retrospectively. Results The average age of 17 patients with ESS was (47.0 ± 10.6) years old, 70.6% of whom were in clinical stage Ⅰ and Ⅱ. Fourteen patients (82.4%) had low-grade ESS and three (17.6%) had high-grade or undifferentiated ESS. The immunohistochemical markers were detected in 17 cases, 5 cases (29.4%) were positive for estrogen receptor (ER), 9 cases (52.9%) were positive for progesterone receptor (PR), 10 cases (58.8% 12 cases (70.6%) expressed p53. Conclusion This group of ESS accounted for 0.61% of the same period of uterine interstitial tumors, and most of the low-grade ESS. p53, CD10 and ER, PR were positive in different degrees.