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目的观察痰热清注射液联合阿糖腺苷注射液治疗手足口病的疗效。方法手足口病患儿160例,随机分为观察组和对照组各80例,观察组给予痰热清联合阿糖腺苷注射液,均1次/d,静脉滴注;对照组给予阿糖腺苷注射液,1次/d,静脉滴注,2组均连续应用5d。观察2组体温恢复至正常的时间、口腔溃疡愈合时间、疱疹消退时间、住院时间,并比较总有效率及不良反应发生情况。结果观察组总有效率(96.3%)高于对照组(85.0%)(P<0.05);观察组体温恢复至正常的时间、口腔溃疡愈合时间、疱疹消退时间及住院时间分别为(2.55±0.35)、(3.06±0.24)、(3.32±0.75)、(5.28±1.34)d,对照组分别为(4.23±0.58)、(5.24±0.84)、(4.30±1.21)、(7.25±1.03)d,2组比较差异均有统计学意义(P<0.05);2组均未发生明显不良反应。结论痰热清联合阿糖腺苷治疗手足口病安全、有效。
Objective To observe the curative effect of Tanreqing injection combined with adenosine injection in the treatment of hand, foot and mouth disease. Methods 160 cases of hand, foot and mouth disease in children, were randomly divided into observation group and control group of 80 cases, the observation group given Tanreqing combined with adenosine injection, were 1 / d, intravenous infusion; control group given sugar Adenosine injection, 1 / d, intravenous infusion, two groups were continuously applied 5d. The body temperature recovered to normal time, oral ulcer healing time, herpes subsidence time and hospital stay were observed in two groups, and the total effective rate and the incidence of adverse reactions were compared. Results The total effective rate (96.3%) in the observation group was higher than that in the control group (85.0%) (P <0.05). The body temperature returned to normal in the observation group, the healing time of oral ulcer, herpes remission and hospital stay were 2.55 ± 0.35 ), (3.06 ± 0.24), (3.32 ± 0.75) and (5.28 ± 1.34) d respectively in the control group were 4.23 ± 0.58, 5.24 ± 0.84, 4.30 ± 1.21 and 7.25 ± 1.03 d, The differences between the two groups were statistically significant (P <0.05). No significant adverse reactions occurred in the two groups. Conclusions Tanreqing combined with vidarabine is safe and effective in the treatment of HFMD.