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目的探讨川芎嗪联合糖皮质激素治疗紫癜性肾炎(HSPN)的临床效果。方法将56例紫癜性肾炎患儿分为治疗组和对照组,随访3个月观察并记录其治疗后尿红细胞和尿蛋白转阴的时间。结果治疗组患儿在起病1个月内尿蛋白转阴者为9例;对照组患儿在1个月内尿蛋白转阴者为4例;治疗组患儿在起病1～3个月内尿蛋白转阴者为10例;对照组患儿在1～3个月内尿蛋白转阴者为5例。两组尿红细胞转阴时间无统计学差异。结论在激素治疗的基础上,加用川芎嗪注射液能有效地缩短紫癜性肾炎患儿尿蛋白转阴的时间。
Objective To investigate the clinical effect of ligustrazine combined with glucocorticoid on purpura nephritis (HSPN). Methods Fifty-six children with purpura nephritis were divided into treatment group and control group. The patients were followed up for 3 months and their urinary red blood cells and urine protein were negative after treatment. Results In the treatment group, the urinary protein was negative in 9 patients within 1 month of onset; in the control group, urine protein was negative in 4 patients in 1 month; in the treatment group, 1 to 3 Month urine protein negative in 10 cases; control group of children within 1 to 3 months urine protein negative in 5 cases. There was no significant difference in urinary red blood cells between two groups. Conclusion On the basis of hormone therapy, adding tetramethylpyrazine injection can effectively shorten the urinary protein in children with purpura nephritis.