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本文对患有间质性肺纤维性病变(IPF)、类肉瘤病及伴有获得性免疫缺陷综合征的肺炎患者,从其肺部洗出吞噬细胞,用脂多糖(LPS)刺激并培养24小时,分离上清液,用胸腺细胞增殖法及概率分析法测定每百万肺泡吞噬细胞IL-1分泌量,并以正常志愿者的肺泡吞噬细胞作为对照。结果显示,患者的肺泡吞噬细胞用LPS刺激后平均比正常机体的肺泡吞噬细胞可分泌更多的IL-1。而且在24名研究对象中(17名患者,7名志愿者),仅仅一名患者和一名志愿者的未受刺激吞噬细胞测出IL-1的自发释放。因此作者认为肺部炎
In this paper, phagocytes were washed out from their lungs in patients with interstitial lung fibrosis (IPF), sarcoidosis and acquired immunodeficiency syndrome, stimulated with lipopolysaccharide (LPS) and cultured 24 Hours, the supernatant was separated, the secretion of IL-1 per million alveolar phagocytes was determined by thymocyte proliferation assay and probability analysis, and the control group was normal alveolar phagocytes. The results showed that, on average, the patient’s alveolar phagocytes, after stimulation with LPS, secrete more IL-1 than normal alveolar phagocytes. Furthermore, the spontaneous release of IL-1 was measured in unstimulated phagocytes in 24 subjects (17 patients, seven volunteers), only one patient and one volunteer. Therefore, the author believes that pulmonary inflammation