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目的:探讨阻塞性黄疸(OJ)患者血清总胆汁酸(TBA)水平与血脂水平的关系。方法:选择2015年5月到2015年12月我院收治的70例OJ患者作为观察组,同期选择70例健康人员作为对照组。检测并比较两组血清TBA、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AI(Apo AI)、载脂蛋白B(Apo B)、脂蛋白α[Lp(α)]、总胆红素(T-Bil)及直接胆红素(D-Bil)水平,并分析血清TBA与血脂水平的关系。结果:观察组患者的血清TBA、TG、TC、Apo B、T-Bil及D-Bil水平均明显低于对照组,血清LDL-C、HDL-C、Apo AI及Lp(α)水平均明显高于对照组,差异均具有统计学意义(P<0.05)。Pearson直线相关性分析结果表明,血清TBA水平与血清TG、TC、Apo B、T-Bil及D-Bil呈正相关性,与血清LDL-C、HDL-C、Apo AI及Lp(α)水平呈负相关性。结论:OJ患者体内存在血脂水平紊乱,血清TBA可能是导致OJ患者血脂代谢紊乱的重要因素。
Objective: To investigate the relationship between serum total bile acid (TBA) and blood lipid in patients with obstructive jaundice (OJ). Methods: Seventy OJ patients admitted to our hospital from May 2015 to December 2015 were selected as observation group and 70 healthy individuals were selected as control group in the same period. The levels of serum TBA, TG, TC, LDL-C, HDL-C, Apo AI ), Apo B, Lp (α), T-Bil and D-Bil were measured and the levels of serum TBA and serum lipid relationship. Results: The levels of serum TBA, TG, TC, Apo B, T-Bil and D-Bil in the observation group were significantly lower than those in the control group, and the levels of serum LDL-C, HDL-C, Apo AI and Lp Higher than the control group, the difference was statistically significant (P <0.05). Pearson’s linear correlation analysis showed that there was a positive correlation between serum TBA levels and serum TG, TC, Apo B, T-Bil and D-Bil, and serum LDL-C, HDL-C, Apo AI and Lp Negative correlation. Conclusion: OJ patients have dyslipidemia in serum and serum TBA may be an important factor leading to dyslipidemia in OJ patients.