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目的探讨利凡诺与米非司酮联合用于中期妊娠引产的效果。方法将219例中期妊娠要求引产的健康妇女随机分为两组,研究组110例经腹羊膜腔内注入利凡诺100mg,于注药当天口服米非司酮50mg,2次/d,总量200mg。对照组109例单用利凡诺引产。结果研究组平均宫缩发动时间、胎儿娩出时间均短于对照组,两组比较差异有统计学意义(P<0.01);产后胎盘、胎膜残留清宫率,研究组为8.18%,对照组为66.97%,两组比较差异有统计学意义(P<0.05);产后2h出血量明显少于对照组,两组比较差异有统计学意义(P<0.05)。结论米非司酮与利凡诺联合引产,使引产总时间明显缩短,引产痛苦减轻,提高引产的有效率,可减少药物用量,降低药物对人体的毒性作用,减少胎盘、胎膜残留,降低清宫率及产后出血量,二者联合有很好的协同作用。
Objective To investigate the effect of rivanol combined with mifepristone on induction of labor during mid-term pregnancy. Methods A total of 219 healthy women, who were asked to give birth during the second trimester pregnancy, were randomly divided into two groups. In the study group, 110 cases received rivaroxurila 100 mg intraabdominal amniocentesis orally. On the day of injection, mifepristone 50 mg, twice daily, 200mg. The control group 109 cases of rivanol alone induced labor. Results The average duration of uterine contractions and fetal delivery in study group were shorter than those in control group, with significant difference between the two groups (P <0.01). The rate of residual cleft of placenta and fetal membrane was 8.18% in study group and 66.97% respectively. The difference between the two groups was statistically significant (P <0.05). The amount of bleeding at 2h postpartum was significantly less than that of the control group. There was significant difference between the two groups (P <0.05). Conclusions Mifepristone combined with Rivanol can shorten the total time of induction of labor, reduce the pain induced by labor and improve the efficiency of induction of labor, reduce the dosage of drugs, reduce the toxic effects of drugs on human body, reduce the residual of placenta and fetal membranes and decrease Qing rate and postpartum hemorrhage, the two have a good synergy.