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目的 :探讨 2 3例Kikuchi淋巴结炎的临床病理特征。方法 :回顾性分析 2 3例Kikuchi淋巴结炎的临床病理资料 ,分别用S -P法和TUNEL法检测免役表型和凋亡。结果 :2 3例中女性 15例 ,男性 8例 ,平均年龄 2 3岁 ,主要症状有发热 (2 0 /2 3 )和颈淋巴结肿大 (2 1/2 3 ) ,外周血白细胞正常或偏低 ,血沉增快 ;组织学上副皮质区和滤泡间出现程度不同的凝固性坏死 ,伴有多种形态的组织细胞、转化的淋巴细胞及凋亡碎片 ,病变区周围有免疫母细胞及浆样单核细胞增生 ,无中性粒细胞浸润。淋巴细胞表达CD3和CD45R0 (+ ) ,CD2 0、CD15 (-) ,组织细胞表达CD68和Lyso(+ ) ,凋亡细胞及碎片TUNEL强阳性。结论 :Kikuchi淋巴结炎显示淋巴结由多种组织细胞、转化T细胞以及凋亡碎片组成的病灶 ,不合并有中性粒细胞浸润。临床上多见于年轻女性 ,常表现为颈淋巴结肿大伴发热 ,临床病理特征复杂 ,易误诊。
Objective: To investigate the clinicopathological features of 23 Kikuchi’s lymphadenitis. Methods: The clinical and pathological data of 23 patients with Kikuchi’s lymphadenitis were retrospectively analyzed. Immunohistochemistry and apoptosis were detected by S-P method and TUNEL method respectively. Results: There were 15 females and 8 males in 23 cases, with a mean age of 23 years. The main symptoms were fever (20/23) and cervical lymph nodes (2/13), peripheral blood leukocytes normal or partial Low, erythrocyte sedimentation rate; Histologically, there are different degrees of coagulation necrosis between the paracortex and follicles, accompanied by various forms of tissue cells, transformed lymphocytes and apoptotic fragments, immune cells around the lesion area and Pulmonary myeloid hyperplasia, no neutrophil infiltration. Lymphocytes expressed CD3 and CD45R0 (+), CD20, CD15 (-), CD68 and Lyso (+) cells, and apoptotic cells and debris TUNEL were strongly positive. CONCLUSIONS: Kikuchi’s lymphadenitis shows lesions consisting of multiple tissue cells, transformed T cells and apoptotic fragments in lymph nodes without neutrophil infiltration. Clinically common in young women, often manifested as cervical lymph node enlargement with fever, complex clinical and pathological features, easily misdiagnosed.