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异烟肼(INH)具有高效、低毒、价廉等特点,在结核病化疗中为首选药物。INH乙酰化代谢型一般分为快型、慢型和中间型。不同乙酰化类型个体间,在临床疗效和毒副作用等方面均存在明显差异,各国学者在测定INH乙酰化分型、分型与疗效、毒副作用和寻求合理给药方案等方面做了不少工作,本文就此问题作一简要综述。
Isoniazid (INH) has the characteristics of high efficiency, low toxicity and low cost, and is the drug of choice in the chemotherapy of tuberculosis. INH acetylated metabolites are generally divided into fast type, slow type and intermediate type. There are significant differences in the clinical efficacy and side effects between different types of acetylation. Scholars in various countries have done a lot of work in the determination of INH acetylation type, typing and curative effect, side effects and seeking rational drug delivery scheme This article gives a brief overview of this issue.